Scientific equipment

Biochemistry & MCB and Biophysics Areas

We use recombinant DNA techniques to express proteins with biotechnological and medical purposes using different expression systems such as E. coli, Pichia pastoris and mammalian cells. The purified proteins/enzymes are characterised by enzymatic assays and other techniques such as CD, absorbance, fluorescence, calorimetry (ITC or DSC) and surface plasmon resonance (SPR).
We also carry out High-Throughput Screening (HTS) to search for potential compounds in cases where the protein/enzymes are potential drug targets or may have biotechnological benefits.
We furthermore complement all the above techniques with protein X-ray crystallography in order to understand the molecular mechanisms of proteins/enzymes or how potential inhibitors/pharmacological chaperones interact with the target proteins.
Finally we further study how the identified compounds act at cellular level by cell biology assays.

Spectroscopy
Calorimetry
Surface Plasmon Resonance (SPR)
Fluorescence Microscopy
High-Throughput Screening (HTS)
Crystallography

Computation, Physics and Innovation Areas

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3D visualization system
Aragrid
Augmented reallity system
Caesaraugusta
Ibercivis
Janus
Piregrid
Terminus