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X-WR-CALDESC:Events for BIFI -  - Institute for Biocomputation and Physics of Complex Systems
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DTSTART;TZID=Europe/Madrid:20231109T100000
DTEND;TZID=Europe/Madrid:20231109T120000
DTSTAMP:20260513T002623
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SUMMARY:II Cycle of young researcher seminars: Pablo Valgañón
DESCRIPTION:“Procesos de reacción-difusión y estrategias de control epidémico”. PABLO VALGAÑÓN \n  \nWednesday\, 8th November\, 2023\n10:00-12:00 h\nSalón de actos.Edificio I+D
URL:https://bifi.es/schedule/ii-cycle-of-young-researcher-seminars-pablo-valganon/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Events
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DTSTART;TZID=Europe/Madrid:20231117T113000
DTEND;TZID=Europe/Madrid:20231117T140000
DTSTAMP:20260513T002623
CREATED:20231114T122305Z
LAST-MODIFIED:20231114T122718Z
UID:7726-1700220600-1700229600@bifi.es
SUMMARY:Webinar Digital Language and Communication Training for EU Scientists
DESCRIPTION:Webinar Digital Language and Communication Training for EU Scientists\, Erasmus + project funded by the European Commission (Project No. 2022-1-ES01-KA220-HED-000086749)\, which will take place this coming Friday\, November 17 at 12.30h. \nIn this seminar there will be brief presentations of the consortium\, its objectives and its planned activities\, related to the following topics: \n– Ethnographies of digital science communication practices.\n– Development of digital resources for the training of researchers in professional and public communication of science.\n– Piloting\, validation and implementation of online training\n– Development of the project’s technological infrastructure and training resources. \nPlease find attached th \nTranslated with www.DeepL.com/Translator (free version) program and some infographics about DILAN. \nRegistration is free and can be done at the following link. Attendance will be certified: \nhttps://forms.gle/fPMjUQQWVDq4sGJU7
URL:https://bifi.es/schedule/webinar-digital-language-and-communication-training-for-eu-scientists/
LOCATION:Online
CATEGORIES:Events
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DTSTART;TZID=Europe/Madrid:20231124T120000
DTEND;TZID=Europe/Madrid:20231124T140000
DTSTAMP:20260513T002623
CREATED:20230912T074821Z
LAST-MODIFIED:20231114T093719Z
UID:7408-1700827200-1700834400@bifi.es
SUMMARY:BIFI TALK: Cristina Mayor Ruiz. IRB Barcelona (Barcelona\, Spain)
DESCRIPTION:BIFI TALK: CRISTINA MAYOR RUIZ \nTitle: Targeted protein degradation: Chasing molecular glues and coping with resistance to degraders \n  \nAbstract: \nTargeted protein degradation is a pharmacological strategy based on drugs (degraders) that destroy proteins by hijacking the intracellular proteolysis machinery. This strategy has garnered significant attention in the last year owing to its potential to modulate the abundance of proteins that are difficult to target with conventional inhibitors. Degraders can be multivalent (PROTACs) or monovalent (molecular glue degraders) depending on the number of chemical warheads. Molecular glue degraders offer a promising strategy for targeting disease-relevant proteins that were previously considered “undruggable”. Mechanistically\, they orchestrate direct protein-protein interactions between a target protein and an E3 ubiquitin ligase.  As a result\, the target protein gets ubiquitinated and then degraded by the proteasome. Despite their great therapeutic potential\, the discovery of molecular glue degraders has been largely serendipitous. I will discuss our efforts to facilitate the rational development of molecular glues. \nIn addition\, many genetic determinants governing degrader efficiency have been mapped in recent years\, bringing important lessons about resistance mechanisms. Our recent chemoproteomics journey aimed at identifying strategies to overcome broad resistance to degraders will be presented. \n  \nFRIDAY\, 24th November 2023\, 12:00 h\nEdificio I+D (Conference room) \n 
URL:https://bifi.es/schedule/bifi-talk-cristina-mayor-ruiz/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Events
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