BIFI - - Institute for Biocomputation and Physics of Complex Systems

XI National Conference BIFI 2023
2023-01-25 - 2023-01-27
The XI National Conference BIFI 2023 (http://bifi23.bifi.es) of the Institute for Biocomputation and Physics of Complex Systems (BIFI) aims at giving all participants the chance to disseminate their work, and at the same time strengthening existing collaborations or establishing new ones within the different research lines promoted by the BIFI.
The format of the congress will include plenary sessions, with invited and contributed talks, as well as the corresponding poster sessions.
MAIN TRACKS:

Biochemistry, Molecular and Cellular Biology
Physics
Biophysics
Computation

CALL FOR COMMUNICATIONS
Researchers from any Institution are warmly invited to attend the meeting, and submit scientific communications related to the Main Tracks of the event. We could limit the attendees number due to a capacity issue at the conference rooms, so that, if necessary, we might reject applications to participate.
IMPORTANT DATES
Dates of the Conference: January 25th – January 27th, 2023.
Registration deadline: December 2nd, 2022.
Abstract submission deadline: December 2nd, 2022.
VENUE
Conference Room, Edificio I+D, Campus Río Ebro.

I CYCLE OF YOUNG RESEARCHER SEMINARS IN THE BIO AREA: ANA JIMÉNEZ ALESANCO
2022-12-14 10:00 - 12:00 (Europe/Madrid) | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
“Drug discovery for inhibiting Bacteroides fragilis toxin: from a chemical screening to an animal model”. ANA JIMÉNEZ ALESANCO
Wednesday, 14 December 2022
10:00-12:00 h
Salón de Actos Edificio I+D

I CYCLE OF YOUNG RESEARCHER SEMINARS IN THE BIO AREA: Mario Tovar Calonge
2022-11-23 10:00 - 12:00 | Salon de actos del edificio I+D
“Forecasting perturbations on mycobacterium tuberculosis transmission with mathematical models: From COVID19-TB syndemics to the evaluation of new vaccines”. MARIO TOVAR CALONGE
Wednesday, 23 November 2022
10:00-12:00 h
Salón de Actos Edificio I+D

I CYCLE OF YOUNG RESEARCHER SEMINARS IN THE BIO AREA: ANDRÉS MANUEL GONZÁLEZ RAMÍREZ
2022-10-05 09:30 - 11:30 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
“Bases estructurales de la Core 1 sintasa”. ANDRÉS MANUEL GONZÁLEZ RAMÍREZ
Wednesday, 5 October 2022
9:30-11:30 h
Salón de Actos Edificio I+D

I CYCLE OF YOUNG RESEARCHER SEMINARS IN THE BIO AREA: Javier Macías León
2022-09-14 10:00 - 12:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
“Estudio de la acción protectora frente a infecciones fúngicas invasivas de un nanobody dirigido al sitio activa de beta-1,3.glucanosiltransferasas”. JAVIER MACÍAS LEÓN
Thursday,14 september,2022
10:00-12:00 h
Aula Edificio I+D

I CYCLE OF YOUNG RESEARCHER SEMINARS IN THE BIO AREA: PABLO FERNÁNDEZ GARRIDO
2022-06-16 10:00 - 12:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
“Nuevos métodos en autoorganización e interfases: experimentación, análisis y simulación”. PABLO FERNÁNDEZ GARRIDO
pablo_f_garrido_a4
Thursday,16 June 2022
10:00-12:00 h
Aula Edificio I+D

The International BIFI 2022 Conference
2022-06-07 09:00 - 2022-06-09 18:00 | Online
The International BIFI 2022 Conference will take place online from February 7th to 9th, 2022. On this occasion the Conference will be focused on the Science of Covid-19: from molecular drug design to data-driven epidemiological models.
In order to ease attendance, this year’s conference will be entirely hosted online.
Every two years the Institute organizes an international conference around its research areas. This is the case of 2022 when we will be holding the BIFI 2022 International Conference which will focus around what we could call the Science of Covid-19. As we well know at this time, the subject is highly topical and possibly expected, but given the massive impact to our societies and its relation to the core activities of our institute, it is also natural choice for 2022. We hope this occasion will serve to consolidate knowledge on the topic, bring new insights and tools to it, and also to fill some gaps and open new research paths. The Conference aims at providing a forum to discuss the latest advances and insights in the study of this pandemic. All topics that fit within the science of COVID-19 from a complexity, biological or interdisciplinary point of view are welcome.
On the website of the event (http://bifi22.bifi.es/) to be announced all the necessary information including the access link in due time.

I CYCLE OF YOUNG RESEARCHER SEMINARS IN THE BIO AREA: Cristina Sarasa Buisán
2022-06-01 10:00 - 12:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
Seminar 2: FurC/PerR de Anabaena sp. PCC7120, un regulador transcripcional que integra dos niveles de respuesta al estrés oxidativo. CRISTINA SARASA BUISÁN
cristina-sarasa-buisan_v4_a4
Wednesday, 1 June 2022
10:00 h
Aula del Edificio I+D

Congreso virtual "Géneros Digitales y Ciencia Abierta"
2022-05-26 - 2022-05-27 | Online
Los días 26 y 27 de mayo se celebrará el Congreso virtual “Géneros Digitales y Ciencia Abierta”. Este congreso es una de las actividades realizadas en el marco del proyecto de investigación PID2019-105655RB-I00 (IIPP María José Luzón Y Carmen Pérez-Llantada). En el congreso se debatirá sobre el impacto de los rápidos desarrollos tecnológicos de la Web 2.0 y el fomento de la ciencia en abierto en las actuales prácticas de comunicación y difusión de la ciencia.
Intervendrán como conferenciantes plenarios:
Prof. Vijay Bhatia (The Chinese University of Hong Kong)
Prof. Christoph Hafner (City University of Hong Kong)
Prof. Benedikt Fecher (Alexander von Humboldt Institute for Internet and
Society)
Prof. Emeritus John M. Swales (University of Michigan, US)
Más información sobre el congreso: http://genci.unizar.es/conference/
Inscripción (gratuita) en la siguiente dirección:
http://genci.unizar.es/conference/

I CYCLE OF YOUNG RESEARCHER SEMINARS IN THE BIO AREA: Helena García Cebollada
2022-05-13 16:00 - 18:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
Seminar 1: Protposer: a web server for rational stabilization of proteins. HELENA GARCÍA CEBOLLADA
seminariohelenagarcia_panoramica-2
Friday 13 May 2022
16:00 horas
Salón de actos del Edificio I+D
¡¡Followed by Happy hour!!

Jornada de Bioingeniería y Biotecnología
2022-04-04 08:30 - 15:00
El próximo lunes 4 de abril se celebrará la Jornada de Bioingeniería y Biotecnología, organizada por los Institutos Universitarios de Investigación (IUIs) de la Universidad de Zaragoza.
El encuentro acomete un doble objetivo:
1) difundir e intercambiar el significativo conocimiento que se genera en la investigación de los institutos en el ámbito de la bioingeniería y biotecnología;
2) generar nuevas colaboraciones multidisciplinares entre distintos grupos con experiencia y capacidades diferentes.
La jornada se celebrará en el Salón de Actos del Edificio I+D del Campus Río Ebro y se podrá seguir presencialmente u online, registrándose previamente en el siguiente enlace Zoom:
https://zoom.us/webinar/register/WN_gYFdy2gDTcKK2U1LgIib6A (tras la inscripción, se recibirá un correo electrónico de confirmación con información para unirse al seminario web).
El programa de la Jornada puede consultarse jornada-bioingeniera-y-biotecnologa_20200404

CIENCIA DIGITAL: SOSTENIBLE, TRANSFORMATIVA Y TRANSVERSAL. RETOS Y PROSPECTIVA
2022-02-22 10:30 - 12:00
CIENCIA DIGITAL: SOSTENIBLE, TRANSFORMATIVA Y TRANSVERSAL. RETOS Y PROSPECTIVA
programa-ciencia-digital_webinar_22-feb-2022_c
Martes 22/02/2022
Hora: 10.30-12.00h
Zoom webinar: https://zoom.us/j/92996415947

BIFI TALK: Dr. Juan Luis Asensio (Instituto de Química Orgánica General, CSIC, Madrid)
2021-12-03 12:30 - 14:30
Title: Glycochemistry and Molecular Recognition: Rational and Combinatorial Approaches
Abstract:
Carbohydrates participate in a large variety of molecular recognition processes of biological relevance, involving both proteins receptors, enzymes and nucleic acid fragments. Understanding how these later bio-molecules interact with glycosides represents a fundamental issue in chemical biology with far reaching implications in fundamental biology, biotechnology or drug design. On the other hand, the acknowledgment of the relevance of glycoconjugates in biology has run parallel to the development of new chemical methods for glycosidic bond formation. Thus, the last few decades have witnessed a burgeoning progress in the area of glycosyl donor engineering, with a more recent focus on the understanding of glycosylation mechanisms. As a part of an ongoing project focused on glycochemisty we
have analyzed different aspects of the association of glycosides to both nulcleic acids and proteins. In addition, key mechanistic features of glycosylation reactions, both in enzymatic nd chemical contexts, have been dissected. From a methodological persepective our approach is pluridisciplinar and includes NMR, molecular modeling, organic synthesis, and a variety of chemical strategies. The obtained results, together with their implications for the design and synthesis of improved carbohydrate-based ligands, will be discussed.
juan-l-asensio_bifitalks2021
FRIDAY, 3rd DECEMBER 2021, 12:30
ONLINE: ZOOM Seminar
Link https://us02web.zoom.us/j/86384158190

BIFI TALK: Dr. Jordi Soriano-Fradera (UBICS, Universitat de Barcelona)
2021-11-12 12:00 - 14:00
Title: Approaches from physics of complex systems to model the brain in vitro
Abstract
Neuroengineering is one of the most exciting techniques in modern neuroscience. The capacity to design controlled environments for the neurons to grow and interconnect is opening new frontiers for the development of accurate in vitro systems that reproduce complex brain functions. In this talk, I will present relatively simple yet
surprisingly enlightening experimental designs that are analyzed in the context of dynamical systems and complex networks. The experiments, and the analytical toolboxes that we derived, are helping us to better understand the intricate relationship between connectivity and dynamics in living neuronal networks, and are opening new avenues for the treatment of neurological disorders.
jordi_soriano_bifitalks2021
BIFI-Talks 2021
12 NOVEMBER 12:00 pm
ONLINE: ZOOM Seminar
Link: https://us02web.zoom.us/j/88242666124

BIFI TALK: Dra. Cintia Roodveldt (investigadora Ramón y Cajal. Universidad de Sevilla)
2021-10-08 12:00 - 14:30
Title: Neurodegenerative proteinopathies: implications and molecular mechanisms of MOK signaling kinase in neuroinflammatory responses.
Abstract:
Neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Amyotrophic lateral sclerosis (ALS) are incurable proteinopathies characterized by progressive neuronal loss, aggregation and deposition of specific proteins in the central nervous system (CNS) and sustained neuroinflammation. In the last few years, it has become increasingly accepted that such protein aggregates have a principal role in triggering neurotoxic immune responses. Still, and particularly for ALS, the molecular mechanisms and proteins participating in these pathogenic processes remain largely unknown. Recently, we have identified MOK Ser/Thr kinase as a TDP-43-interacting protein in an ALS microglial cell model (Leal-Lasarte et al., FASEB J. 2017). Our recent studies, involving biochemical, transcriptomic and interactomic approaches, shed light on the role and molecular mechanisms of MOK in dysregulated immune responses in ALS and other related diseases.
cintia-roodveldt_bifitalks2021
FRIDAY, 8th OCTOBER 2021, 12:00
ONLINE: ZOOM Seminar
Link: https://us02web.zoom.us/j/85809480012

BIFI TALK: Dr. Sandro Meloni (CSIC-UIB)
2021-06-04 12:30 - 14:30
Title: Ecology of Online Social Systems
Abstract
Online social networks have significantly changed global communication dynamics and, in general, the way we interact. Every day our brain is flooded by information coming from a plethora of sources and this cognitive bottleneck translates into hyper-competition for a scarce resource: our attention. This pressure, in turn, pushes information producers to mutualistically interact with specific memes and actors, seeking the virality of their messages. Finally, memes’ chances to persist and spread are subject to changes in the communication environment. The fact that all these terms — competition for resources, mutualism and environmental changes– are
reminiscent of another research field –ecology–, suggests that, at least at a coarse-grained level, “information” ecosystems and natural ecosystems present strong similarities that can be exploited to understand their behavior.
In this talk, building on these analogies, I will show how theories and tools developed for the study of ecological communities help to gain insights on human behavior in online social interactions. In the first part, I will introduce an analytical formalism –based on the neutral theory of ecology–, capable of capturing the competition for attention and explaining several emergent patterns observed in information ecosystems. In the second part, using both
data analysis and numerical modeling, I will focus on the structure of information ecosystems showing that the underlying architecture of empirical actor-meme networks evolves towards self-similar nested arrangements like the ones found in natural mutualistic assemblages.
meloni_bifitalks2021
DIA Y HORA: 4 DE JUNIO A LAS 12:30
ONLINE: ZOOM Seminar
Seminar Link: https://us02web.zoom.us/j/88679866793

Conferencia invitada. Francisco Castejón (Consejo de Seguridad Nuclear)
2021-05-28 12:00 - 14:00
Transformando el Consejo de Seguridad Nuclear para mejorar la seguridad nuclear y la protección radiológica.
El papel del Consejo de Seguridad Nuclear (CSN) en el contexto de la situación actual será el tema central de la conferencia. La renovación en la que se encuentra inmerso dicho organismo pretende aportar mas transparencia con el fin de generar mas confianza y seguridad en la sociedad. En este sentido la ciencia ciudadana podría jugar un papel importante.
Dia: 28 de Mayo 2021,
Hora: 12 h
Lugar: Aula Magna del Paraninfo de la Universidad de Zaragoza. Edificio Paraninfo.
Plaza de Paraíso 4. Zaragoza

BIFI TALK: Prof. Nuria Verdaguer (IBMB-CSIC, Barcelona)
2021-05-07 12:30 - 15:00
Title: From structure to mechanisms of Zika virus induced neurodevelopmental disease
Abstract:
Zika virus (ZIKV) infection was declared a global threat for public health due to its association with congenital neurodevelopmental birth defects, such as microcephaly, a rare medical condition characterized by a significant decrease in brain size. ZIKV infection delays cell cycle progression and induces cell death of neural progenitor cells (NPCs), leading to reduced production of neurons. Despite the enormous basic and clinical research efforts, no specific therapy has yet been approved for the treatment or prevention of ZIKV infection, thus a better understanding of its pathogenesis is an urgent need.
Our recent studies of the effect of ZIKV proteins on NPC proliferation show that the protein NS5 that is essential for viral genome replication, is also sufficient to alter the mode of division of NPCs. NS5 interacts and depletes primary cilia and centrosome components, causing an atypical non-genetic ciliopathy and premature neuron delamination. While the Methyltransferase (MTase) and RNAdependent RNA polymerase (RdRP) activities of ZIKV-NS5
appear to be dispensable, the Y25, K28 and K29 residues that are involved in NS5 oligomerization, are essential for the localization and interactions with proteins of the cilia base, promoting ciliopathy and premature neurogenesis. In
this talk I will summarize our recent findings, exploring these unexpected interactions between ZIKV-NS5 and different cilia/centrosome proteins. These data will shed new light into the mechanisms by which NS5 interferes with the molecular machinery of primary cilia formation, highlighting new potential targets for therapeutic intervention.
nuria-verdaguer_bifitalks2021
BIFI-Talks 2021
DIA Y HORA: 7 DE MAYO A LAS 12:30
ONLINE: ZOOM Seminar
Link: https://us02web.zoom.us/j/83011713089

BIFI TALK Dr. Ernesto Estrada (ARAID-IUMA-Universidad de Zaragoza)
2021-04-16 12:30 - 15:30
Tittle: Networks Virology. Learning from SARS-CoV-2
Abstract:
Viruses are reproductive machineries formed mainly by genetic material (RNA or DNA) and proteins. In general, these proteins interact with specific proteins of the host forming vast networks of virus-host protein-protein interactions (PPI). Although a virus may infect mainly an organ or system of the host, the damages can propagate beyond it, transforming the affection into a multiorganic/multifunctional one. This is the case of SARS-CoV-2, which makes COVID-19 a multiorganic disease affecting a dozen of organs/systems in humans. Here, I develop the hypothesis based on facts that this propagation of extrapulmonary damages takes place via the PPI network of virus-host interactions. It considers that some viral proteins interact with specific human proteins highly expressed in the lungs. Then, these perturbed human proteins navigate outside the lungs via an exosome-mediated transport network, which allows the inter-organ cross-talk. Due to the fact that these “perturbated” proteins interact with their partners in other organs they are capable to transmit such perturbations beyond the lungs. Therefore, there is a network of perturbators from the lungs interacting with a network of vulnerable proteins in other organs, which trigger a range of damages in them. We identify here the perturbators and vulnerable proteins in COVID-19, identifying 13 organs/systems that may be affected by the infection of SARS-CoV-2 and explain some of the extrapulmonary damages observed in clinics. We propose a series of drugs that can be repurposed to treat combinations of these damages in COVID-19 patients. Finally, at a lower size-scale we zoom on these SARS-CoV-2 proteins to investigate their topological structure, which form other networks of amino-acids interacting noncovalently among them. Using these techniques, we are able to identify weak pints in such proteins that can be used as pharmacological targets.
estrada_bifitalks2021
16 APRIL 12:30
ONLINE: WEBINAR ZOOM
Link: https://us02web.zoom.us/j/84993664074

BIFI TALK. Dr. Enrique Marcos (IBMB-CSIC, Barcelona)
2021-03-19 12:30 - 14:00
Title: De novo protein design for tailoring structure and function
Speaker: Dr. Enrique Marcos (IBMB-CSIC, Barcelona)
Abstract:
The recent revolution of de novo protein design is transforming the protein engineering field. Instead of searching and modifying natural proteins, de novo protein design crafts new proteins from physical principles with sequences and geometries not restricted to those seen in nature. From scratch, protein backbones are computationally generated according to geometrical
restrictions defined by the designer, followed by the calculation of low-energy amino acid sequences stabilizing these backbones. In this way, protein
structures are tailored for stability and function; potentially overcoming frequent limitations of repurposed natural proteins in terms of stability, geometry, size, recombinant expression or protein interactions, among others. We have identified key principles for the de novo design of a variety of protein folds containing beta-sheets, which are attractive structural motifs for building ligand-binding sites, and used these principles for computationally designing proteins in excellent agreement with their experimental structures. This has opened the door to custom-design proteins for binding small-molecules and protein targets of therapeutic relevance. De novo proteins allow us to explore a vast sequence and structural space to develop novel biotechnological
solutions, and ultimately advance our understanding on how proteins work.
enrique-marcos_bifitalks2021
DIA Y HORA: 19 DE MARZO A LAS 12:30
ONLINE: Meeting ZOOM
Link: https://us02web.zoom.us/j/85377863712

X National Conference BIFI 2021
2021-02-03 - 2021-02-05
The X National Conference BIFI 2021 (http://bifi21.bifi.es) of the Institute for Biocomputation and Physics of Complex Systems (BIFI) aims at giving all participants the chance to disseminate their work, and at the same time strengthening existing collaborations or establishing new ones within the different research lines promoted by the BIFI.
The format of the congress will include plenary sessions, with invited and contributed talks, as well as the corresponding poster sessions.
MAIN TRACKS:

Biochemistry, Molecular and Cellular Biology
Physics
Biophysics
Computation

CALL FOR COMMUNICATIONS
Researchers from any Institution are warmly invited to attend the meeting, and submit scientific communications related to the Main Tracks of the event. We could limit the attendees number due to a capacity issue at the conference rooms, so that, if necessary, we might reject applications to participate.
IMPORTANT DATES
Dates of the Conference: February 3 – February 5, 2021
Registration deadline: January 31st 2021
Abstract submission deadline: January 8 th, 2021
Notification to authors: not later than January 15th, 2021
VENUE
Zoom I+D Room

CURSO DE INVIERNO DE LA UNIVERSIDAD DE ZARAGOZA Nuevas perspectivas en la evolución de los genes y proteínas / Advances in Genome and Protein Evolution 28-29 de Febrero en Jaca (Huesca)
2020-02-28 08:00 - 2020-02-29 17:00
Abierta la Inscripción del CURSO DE INVIERNO DE LA UNIVERSIDAD DE ZARAGOZA Nuevas perspectivas en la evolución de los genes y proteínas / Advances in Genome and Protein Evolution 28-29 de Febrero en Jaca (Huesca) en https://cursosextraordinarios.unizar.es/cursos-invierno
Las personas interesadas en pedir una ayuda económica para asistir a dicho curso deben inscribirse ahora pero NO pagar la matrícula de momento. Para solicitar la ayuda deberán escribir a i.yruela@csic.es y mmartine@unizar.es adjuntado un breve CV. El plazo límite para pedir esta ayuda es el 28 de Enero de 2020.
INFORMACIÓN CURSO
Dirección: Inmaculada Yruela y Marta Martínez Júlvez
Ponentes y sesiones:
Pilar Catalán, Universidad de Zaragoza
-Phylogenetic concepts. Organismal phylogenetic reconstruction and evolutionary speciation events
-Phylogenetic methods. From distance-based methods to the coalescent approach

Inmaculada Yruela, CSIC, Zaragoza
-Introduction to sequence analysis and protein phylogeny
Toni Gabaldón, Supercomputing Centre (BSC-CNS) and Institute for Research in Biomedicine (IRB), Barcelona
-Homology, orthology and paralogy
-Comparative genomics and phylogenomics

Ugo Bastolla, Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid
–Detecting selection on protein structure and protein folding stability
-Substitution processes with selection on protein structure and protein folding stability
Leandro Radutsky, Centro de Regulación Genómica (CRG), Barcelona
-Structural bioinformatics for the analysis of protein mutations with focus on disease and evolution
Dirigido a: Estudiantes de los últimos cursos de los grados en Química, Biología, Física, Farmacia, Medicina, Bioquímica, Biotecnología, Veterinaria. Estudiantes de másteres de Química Molecular, Bioquímica, Biología Molecular y Celular, Biomedicina, Biotecnología. Estudiantes de doctorado. Profesionales en activo en cualquiera de las áreas de conocimiento y especialidades anteriormente enumeradas.
Este curso tiene reconocidos 0,5 ECTS como Formación Permanente de Profesorado

BIFI TALK. Fabio Dercole
2020-02-10 12:30
Title: Direct reciprocity and model-predictive strategy update explain the network reciprocity observed in socio-economic networks
Speaker: Fabio Dercole
Abstract:
Network reciprocity has been successfully put forward (since M.A. Nowak & R. May’s, 1992, influential paper) as the simplest mechanism — requiring no strategical complexity — supporting the evolution of cooperation in biological and socio-economic systems. The mechanism is actually the network, that makes agents’ interactions localized, while network reciprocity is the property of the underlying evolutionary process of favoring cooperation in sparse rather than dense networks. In theoretical models, the property holds under imitative evolutionary processes, that however lack rationality in the socio-economic context, whereas cooperation disappears in any network if imitation is replaced by the more rational best-response rule of strategy update. In social experiments, network reciprocity has been observed, though the imitative behavior did not emerge. What did emerge is a form of conditional cooperation based on direct reciprocity—the propensity to cooperate with neighbors who previously cooperated. To resolve this inconsistency, we show network reciprocity in a model that
rationally confronts the two main behaviors emerging in experiments — reciprocal cooperation and unconditional defection — with rationality introduced by means of a multi-step model-predictive rule for strategy update.
Sala de Conferencias, Edif. I+D, Campus Rio Ebro
LUNES 10 de FEBRERO a las 12:30h

IX International BIFI 2020 Conference
2020-02-03 11:00 - 2020-02-05 13:00
La IX Conferencia Internacional BIFI 2020 tendrá lugar en Zaragoza, en el salón de actos del Edificio I+D, Campus Río Ebro (Actur), del 3 al 5 de febrero del año próximo 2020.
En esta ocasión (la conferencia) está enfocada en “Nuevos retos en Biotecnología Molecular (New Challenges in Molecular Biotechnology). Así, hemos preparado un programa científico con oradores invitados nacionales e internacionales que creemos que es muy atractivo. El formato del evento incluye sesiones plenarias con 18 charlas, 5 de las cuales serán impartidas por prominentes investigadores que realizan su investigación en reconocidos centros como el Instituto Pasteur de Paris, la Unidad de Biología Mitocondrial de Cambridge, la Estación Experimental de Aula Dei (CSIC) de Zaragoza, el Instituto Rocasolano de Madrid, y el Laboratorio de Sistemas Bioquímicos (CIB-CSIC), también de Madrid. Nueve de los trabajos inscritos serán elegidos para impartir charlas cortas de 12 min (+3 de preguntas) y se han programado dos sesiones para la presentación de pósters de los cuales serán premiados dos con las cantidades de 300€ (Primer premio) y 200€ (Segundo premio).
Invitamos cordialmente a los investigadores jóvenes y a aquellos no tan jóvenes, también a estudiantes, a asistir a esta nueva edición de nuestra Conferencia bienual y a enviar comunicaciones científicas relacionadas con los temas principales del evento. Queremos en este marco brindaros la oportunidad de difundir vuestro trabajo y de poder crear y/o fortalecer nuevas colaboraciones científicas.
Los plazos de inscripción son: 20 de diciembre (Early) y 10 de enero (Late), con diferentes importes de las cuotas de inscripción (vea las diferentes opciones en el sitio del evento). La notificación por parte del Comité Organizador a aquellos cuyos trabajos resultasen elegidos para impartir charlas cortas se realizará como muy tarde el día 17 de enero de 2020.
En el sitio web del evento (http://bifi20.bifi.es/) podrás encontrar toda la información necesaria para inscribirte, así como el Programa Científico, elementos importantes sobre nuestro Instituto (el lugar de celebración de la Conferencia), la ciudad de Zaragoza y más.
Si estás interesado/a en asistir, por favor regístrate cuanto antes.
Desde ya os damos la bienvenida en Zaragoza.
El Comité Organizador

IX International BIFI 2020 Conference
2020-02-03 10:00 - 2020-02-05 13:00
The IX International BIFI 2020 Conference will take place in Zaragoza, in the auditorium of the R+D Building, Río Ebro Campus (Actur), from February 3rd to 5th, 2020.
On this occasion the Conference will be focused on “New Challenges in Molecular Biotechnology“. Thus, we have prepared a scientific program with national and international speakers that we believe is very attractive. The event format includes plenary sessions with 18 talks by invited speakers, 5 of which will be given by prominent researchers who conduct their research in renowned research centers such as the Pasteur Institute in Paris, the Mitochondrial Biology Unit in Cambridge, the Estación Experimental de Aula Dei (CSIC ) in Zaragoza, the Rocasolano Institute in Madrid, and the Laboratory of Systems Biochemistry (CIB-CSIC) also in Madrid. In addition, nine of the works submitted will be chosen to give short oral talks of 12 min (+3 question-minutes). Two Poster sessions have been scheduled from which two works presented in this modality will be awarded with the amounts of €300 (First prize) and €200 (Second prize).
We warmly invite young and not so young researchers, and also students, to attend this new edition of our biennial conference and to send scientific communications related to the main tracks of the event. Our main purpose is giving you the opportunity to communicate your research and to create and/or strengthen new scientific collaborations.
Registration deadlines will be December 20th (Early) and January 10th (Late), with different registration fees in each case (see the different options on the event site). Notification by the Organizing Committee to those whose works were chosen to give short oral talks will be made at the latest on January 17th, 2020.
On the website of the event (http://bifi20.bifi.es/) you will find all the necessary information to register, also the Scientific Program, as well as important aspects about the BIFI Institute (the venue of the Conference), the city of Zaragoza, and more.
If you are interested in attending, please register as soon as possible.
We welcome you in Zaragoza.

BIFI TALK - Javier Oroz
2019-12-13 12:30 - 14:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
Título: Structural biology in human disease: What can we learn from the study of disordered proteins?

Ponente: Javier Oroz (IQFRS-CSIC, Madrid)
Día y hora: 13 de diciembre a las 12.30
Lugar: SALA DE CONFERENCIAS, EDIFICIO I+D+i, CAMPUS RIO EBRO

BIFI TALK - Javier Galeano
2019-11-08 12:30 - 14:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
Título: A quick review of ecology of bacteriaA quick review of ecology of bacteria
Ponente: Javier Galeano (UPM, Madrid)
Día y hora: 8 de noviembre a las 12.30
Lugar: SALA DE CONFERENCIAS, EDIFICIO I+D+i, CAMPUS RIO EBRO

BIFI TALK - Javier García-Nafría
2019-10-04 13:00 - 14:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
Título: Cryo-electron microscopy: moving beyond X-ray crystallography for membrane receptors and drug discovery

Ponente: Javier García-Nafría (LMB/MRC, Cambridge, UK-University of Zaragoza)
Día y hora: 4 de octubre a las 13:00 h
Lugar: SALA DE CONFERENCIAS, EDIFICIO I+D+i, CAMPUS RIO EBRO
Resumen:
Cryo-electron microscopy (cryo-EM) has undergone major advances during the last years, with special impact in structural biology of membrane proteins. I will review the advances in cryo-EM technology that made the ¨resolution revolution¨ possible, and then show its application to understand G-protein coupled receptors (GPCRs). GPCRs are the largest family of membrane proteins in the human body and are a target for ~35% of the currently approved FDA drugs. GPCRs sense a variety of molecules and transduce the signal to the intracellular milieu by coupling to heterotrimeric G-proteins. We used cryo-EM to obtain high-resolution structural information on GPCR-G protein complexes, starting to tackle one of the major questions in the field – the GPCR-G protein selectivity code. I will then analyse the state-of-the-art in using cryo-EM for structure-based drug discovery of membrane proteins.
References:

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein. García-Nafría J.*, Lee Y.*, Bai X., Carpenter B. & Tate CG. 2018. Elife. May 4;7. pii: e35946.

Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go. García-Nafría J., Nehme R., Edwards P., Tate CG. 2018. Nature 558 (7711). 620-62

Cryo-EM structures of GPCRs coupled to Gs, Gi and Go. García-Nafría J. and Tate CG. Molecular and Cellular Endocrinology. 2019, In press.

Cryo-Electron Microscopy: Moving Beyond X-ray Crystal Structures for Drug receptors and Drug development. García-Nafría J. and Tate CG. 2019. Annual Reviews in Pharmacology and Toxicology. 2020. In press (2019 Jul 26. doi: 10.1146.)

BIFI TALK - Joaquín Marro
2019-06-07 12:30 - 14:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
Título: Por confirmar
Ponente: Joaquín Marro
Día y hora: 7 de junio a las 12.30
Lugar: SALA DE CONFERENCIAS, EDIFICIO I+D+i, CAMPUS RIO EBRO

BIFI TALK - Mónica Balsera
2019-05-10 12:30 - 14:00 | Edificio Institutos I+D, Mariano Esquillor, 50018 Zaragoza, Zaragoza, Zaragoza, 50018, España
Título: Por confirmar
Ponente: Mónica Balsera (IRNASA -CSIC, Salamanca)
Día y hora: 10 de Mayo a las 12.30
Lugar: Aula, EDIFICIO I+D+i, CAMPUS RIO EBRO
