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X-WR-CALDESC:Events for BIFI -  - Institute for Biocomputation and Physics of Complex Systems
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DTSTART;TZID=Europe/Madrid:20261009T123000
DTEND;TZID=Europe/Madrid:20261009T140000
DTSTAMP:20261106T192656
CREATED:20261008T100105Z
LAST-MODIFIED:20261008T100105Z
UID:10865-1791549000-1791554400@bifi.es
SUMMARY:BIFI TALK: Andrea Ilari\, Istituto di Biologia e Patologia Molecolari\, IBPM of CNR  c/o Dip. Scienze Biochimiche Università Sapienza\,Roma
DESCRIPTION:[vc_row][vc_column][vc_column_text css=”.vc_custom_1791453588217{margin-bottom: 0px !important;}”]BIFI TALK: Andrea Ilari\, Istituto di Biologia e Patologia Molecolari\, IBPM of CNR  c/o Dip. Scienze Biochimiche Università Sapienza\, P.le Aldo Moro 5\, 00185 Roma \nTítulo: Exploiting a Druggable E2 Ubiquitin Conjugating Enzyme and an E3 Ligase for PROTAC-Mediated Degradation of Trypanothione Reductase in Leishmania \nAbstract \nLeishmaniasis is a neglected tropical disease affecting up to one million people annually according to the World Health Organization. Visceral leishmaniasis\, caused by Leishmania infantum\, is the most severe form of the disease and can be fatal if left untreated. Current therapies are limited by toxicity\, variable efficacy\, lengthy treatment regimens\, and the emergence of drug resistance [1]. \nThe parasite survives the oxidative burst generated by host macrophages through a unique trypanothione-based redox system\, whose central enzyme\, trypanothione reductase (TR)\, maintains trypanothione in its reduced state. Owing to its essential role in parasite survival\, absence in humans\, and favorable druggability profile\, TR has long been considered an attractive therapeutic target. However\, despite decades of research\, no TR inhibitors have advanced to clinical development\, mainly because of insufficient efficacy and safety concerns [2]. \nTargeted protein degradation has recently emerged as an alternative therapeutic strategy capable of eliminating\, rather than inhibiting\, disease-relevant proteins. PROteolysis TArgeting Chimeras (PROTACs) are bifunctional molecules that induce ubiquitination and subsequent proteasomal degradation of a target protein by recruiting components of the ubiquitin–proteasome system (UPS) [3]. As first step\, we developed TR-targeting PROTACs designed to recruit a putative Leishmania E3 ligase\, but their activity was modest and the recruited E3 remains poorly characterized. To overcome these limitations\, we propose an innovative E2-recruiting PROTAC strategy that bypasses the requirement for a defined E3 ligase. As a first step\, we structurally and functionally characterized a Leishmania major ubiquitin-conjugating enzyme (E2). Crystallographic fragment screening identified potential ligandable sites on the enzyme\, while DeepFrag-guided fragment expansion and AutoDock Vina docking were employed to generate and prioritize E2-binding chemotypes. Together\, these studies establish the molecular framework for the rational development of E2-recruiting PROTACs targeting TR and open new opportunities for exploiting the ubiquitin–proteasome system in antileishmanial drug discovery [4]. \nReferences \n[1] S. Pradhan\, R. A. Schwartz\, A. Patil\, S. Grabbe\, and M. Goldust\, Clin Exp Dermatol\, 2022\, 47\, 516.\n[2] T. Battista\, G. Colotti\, A. Ilari\, and A. Fiorillo\, Molecules\, 2020. 25\, 1924.\n[3] S. Gu\, D. Cui\, X. Chen\, X. Xiong\, and Y. Zhao\, BioEssays\, 2018\, 40\, e1700247.\n[4] C. Exertier\, L. Antonelli\, A. Liuzzi\, M. Ruffa\, V. Brufani\, G. Colotti\, A. Fiorillo\, A. Ilari; ACS Omega 2026; https://doi.org/10.1021/acsomega.6c05158[/vc_column_text][/vc_column][/vc_row]
URL:https://bifi.es/schedule/bifi-talk-andrea-ilari-istituto-di-biologia-e-patologia-molecolari-ibpm-of-cnr-c-o-dip-scienze-biochimiche-universita-sapienzaroma/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20261106T120000
DTEND;TZID=Europe/Madrid:20261106T120000
DTSTAMP:20261106T192656
CREATED:20261029T134450Z
LAST-MODIFIED:20261029T134510Z
UID:10935-1793966400-1793966400@bifi.es
SUMMARY:BIFI TALK: Miguel Brun-Usan de la Universidad Autonoma de Madrid
DESCRIPTION:[vc_row][vc_column][vc_column_text css=”.vc_custom_1793281425624{margin-bottom: 0px !important;}”]Miguel Brun-Usan de la Universidad Autonoma de Madrid \nTitle: From Genes to Organisms: Modeling Biological Complexity Across Scales \nAbstract: From gene regulatory networks and individual cells to tissues\, organisms\, and ecosystems\, biological systems are remarkably complex. Much of this complexity emerges through bottom-up processes\, that is\, through interactions between individual components at lower levels of organization that give rise to collective (self-)organization. At the same time\, global constraints and emergent structures at larger scales shape the behavior of individual components in a top-down manner. Understanding this dynamic\, bidirectional interplay across biological scales remains a fascinating and challenging problem. \nIn this talk\, I will present an illustrated tour of mathematical and computational approaches to investigating these multilevel causal cascades\, drawing on concepts and tools from network theory\, learning theory\, dynamical systems theory\, and topological data analysis. The examples will be drawn primarily from problems I have worked on and am currently exploring\, with particular emphasis on embryonic development (arguably an epitome of complex systems)\, where the spatiotemporal coupling between gene regulatory network dynamics and morphogenesis drives the emergence of complex phenotypes\, which in turn provide the substrate for open-ended evolution. \nFinally\, I will discuss the limitations of current modeling approaches\, highlight open questions\, and explore potential directions for future research and interdisciplinary collaboration. \nSalón de actos Edificio I+D[/vc_column_text][/vc_column][/vc_row]
URL:https://bifi.es/schedule/bifi-talk-miguel-brun-usan-de-la-universidad-autonoma-de-madrid/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20261120T093000
DTEND;TZID=Europe/Madrid:20261120T143000
DTSTAMP:20261106T192656
CREATED:20261030T093601Z
LAST-MODIFIED:20261030T094236Z
UID:11003-1795167000-1795185000@bifi.es
SUMMARY:Supercomputing\, Science and Society: Scientific Workshop in Honor of Alfonso Tarancón's Career
DESCRIPTION:[vc_row][vc_column][vc_column_text title=”A Tribute to a Career” css=”.vc_custom_1793352829615{margin-bottom: 0px !important;}”]\n\n\nOn the occasion of his 70th birthday and retirement\, we would like to pay tribute to Alfonso Tarancón and recognize his outstanding scientific career in the fields of computational physics and supercomputing. For decades\, his work has contributed to the development of these disciplines and left a lasting impact on both research and everyone who has had the opportunity to work\, collaborate\, and learn alongside him.\n\nOn November 20\, we will hold a special scientific workshop in his honor\, bringing together colleagues\, collaborators\, and friends. Through a series of talks given by peers and collaborators who have shared parts of his journey\, we will review some of the main lines of research that have marked his career: from the development of special-purpose computers for scientific simulations to the applications of advanced computing in science and society.\n\nIt will be an occasion to share experiences\, look back on past projects\, highlight his contributions\, and celebrate both his scientific legacy and the beginning of a new chapter.\n\nDate: November 20\nVenue: Sala de Grados\, Faculty of Sciences\, University of Zaragoza (San Francisco Campus)\nAddress: C/ Pedro Cerbuna\, 12\, 50009 Zaragoza\, Spain\n\nWe look forward to welcoming you to this day of science\, recognition\, and celebration.\n\n[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1793352684136{margin-bottom: 0px !important;}”]\n\n\n\n\n\n \n\n\nTIME\nSPEAKER\nTOPIC\n\n\n\n\n9:30 – 9:45\nDavid Íñiguez Dieste\nTBA\n\n\n9:45 – 10:00\nJuan J. Ruiz-Lorenzo\nTBA\n\n\n10:00 – 10:15\nSergio Pérez Gaviro\nTBA\n\n\n10:15 – 10:30\nVíctor Martín-Mayor\nTBA\n\n\n10:30 – 10:45\nEnzo Marinari\nTBA\n\n\n10:45 – 11:00\nJesús Clemente Gallardo\nTBA\n\n\n11:00 – 11:45  |  BREAK & GROUP PHOTO\n\n\n11:45 – 12:00\nFrancisco Castejón\nTBA\n\n\n12:00 – 12:15\nJacobo Cano de Escoriaza\nThe Human Side of Research Excellence with Social Impact\n\n\n12:15 – 12:30\nSantos Orejudo\nTBA\n\n\n12:30 – 12:45\nIsabel Campos\nTBA\n\n\n12:45 – 13:00\nCarlos López Ullod\nTBA\n\n\n13:00 – 13:15\nYamir Moreno\nComplex systems through the lens of networks\n\n\n13:15 – 13:30  | CLOSING REMARKS & WRAP-UP\n\n\n14:15  |  LUNCH\n\n\n\n\n[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text title=”LUNCH” css=”.vc_custom_1793352754209{margin-bottom: 0px !important;}”]After the workshop\, we will gather for lunch to continue the celebration.\nIf you would like to join us\, please sign up using the following form:\nSign up for the lunch\nRegistration deadline: Thursday\, November 5.[/vc_column_text][vc_column_text title=”Organizing Committee” css=”.vc_custom_1793352922022{margin-bottom: 0px !important;}”]\nJosé Manuel Carmona Martínez \nJesús Clemente Gallardo \nDavid Íñiguez Dieste \nSergio Pérez Gaviro \nDavid Yllanes Mosquera \n[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_images_carousel images=”10947\,10957\,10959″ css=””][/vc_column][/vc_row]
URL:https://bifi.es/schedule/supercomputing-science-and-society-scientific-workshop-in-honor-of-alfonso-tarancons-career/
LOCATION:Sala de Grados\, Facultad de Ciencias\, Universidad de Zaragoza (Campus San Francisco)\, C/ Pedro Cerbuna\, 12 - 50009 Zaragoza\, Zaragoza\, Zaragoza\, 50009\, Spain
CATEGORIES:Events
ATTACH;FMTTYPE=image/jpeg:https://bifi.es/wp-content/uploads/2026/10/alfonso-tarancon-director-del-centro-de-supercomputacion-de-aragon.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20270525
DTEND;VALUE=DATE:20270528
DTSTAMP:20261106T192656
CREATED:20261022T133201Z
LAST-MODIFIED:20261022T133201Z
UID:10887-1811203200-1811462399@bifi.es
SUMMARY:XIV BIFI INTERNATIONAL CONFERENCE
DESCRIPTION:[vc_row][vc_column][vc_column_text css=”.vc_custom_1792675895733{margin-bottom: 0px !important;}”]14th International BIFI Conference \nOrganized by the Institute for Biocomputation and Physics of Complex Systems at the University of Zaragoza\, the 14th International BIFI Conference will take place in Zaragoza\, Spain\, from May 25th to 27th\, 2027. This international forum brings together researchers\, educators\, science communicators\, and early-career scholars within the Science 2.0 ecosystem to explore the dynamic intersections of scientific research\, public outreach\, and digital media. \nBy bridging genre\, linguistic and communication analysis with core scientific disciplines—such as biochemistry\, cellular and molecular biology\, physics\, biophysics\, and computation—the conference provides a unified platform to reframe how scientific knowledge circulates and impacts society. Beyond discourse analysis\, participants will showcase the practical applications of computational models\, interactive data visualizations\, and Open Science workflows to tackle complexity\, automate discovery\, and drive social transformation. \nWe warmly invite researchers across all related fields to take part\, foster interdisciplinary collaborations\, and present their work. \n  \nMAIN STRANDS \nWe invite contributions for the following strands: \nStrand 1: Genres and the new ecosystem of scholarly communication\nStrand 2: Digital genres and multimodal knowledge circulation\nStrand 3: Social impact\, outreach\, and professional development\nStrand 4: Computation\, biophysics\, physics\, Biochemistry\, Molecular and Cellular biology (BIFI Sessions)\nStrand 5: Participatory dynamics and Citizen Science\nStrand 6: The impact of AI in scientific research communication and dissemination \n  \nIMPORTANT DATES \nSubmission deadline: January 10\, 2027\nNotification of acceptance: January 31\, 2027\nConference dates: May 25-27\, 2027[/vc_column_text][/vc_column][/vc_row]
URL:https://bifi.es/schedule/xiv-bifi-international-conference/
LOCATION:IberCaja – Patio de la Infanta Center (Obra Social IberCaja)
CATEGORIES:Congresses
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