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X-WR-CALDESC:Events for BIFI -  - Institute for Biocomputation and Physics of Complex Systems
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DTSTART;TZID=Europe/Madrid:20170707T113000
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DTSTAMP:20260428T011722
CREATED:20170706T103451Z
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SUMMARY:BIFI Talk: Seminario del profesor Philip Hardwidge
DESCRIPTION:Título: Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production \nPonente: Philip R. Hardwidge Kansas State University \nDía y hora: Viernes 7 de julio a las 11:30 h. \nLugar: SALA DE CONFERENCIAS\, EDIFICIO I+D+i\, CAMPUS RIO EBRO \n  \nAbstract: \nCitrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production \nPhilip R. Hardwidge Kansas State University \nInterferon signaling plays important roles in both intestinal homeostasis and in the host response to pathogen infection. The extent to which bacterial pathogens inhibit this host pathway is an understudied area of investigation. We characterized Citrobacter rodentium strains bearing deletions in individual type III secretion system effector genes to determine whether this pathogen inhibits the host type I interferon (IFN) response and which effector is responsible. The NleB effector limited host IFN-beta production by inhibiting Lysine 63-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3). Inhibition was dependent on the glycosyltransferase activity of NleB. GAPDH\, a target of NleB during infection\, bound to TRAF3 and was required for maximal TRAF3 ubiquitination. NleB glycosyltransferase activity inhibited GAPDH-TRAF3 binding\, resulting in reduced TRAF3 ubiquitination. Collectively\, our data reveal important interplay between GAPDH and TRAF3 and suggest a mechanism by which the NleB effector inhibits type I IFN signaling.
URL:https://bifi.es/schedule/seminario-del-profesor-philip-hardwidge/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Events
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