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DTSTART;TZID=Europe/Madrid:20210416T123000
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DTSTAMP:20260426T013318
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SUMMARY:BIFI TALK Dr. Ernesto Estrada (ARAID-IUMA-Universidad de Zaragoza)
DESCRIPTION:Tittle: Networks Virology. Learning from SARS-CoV-2 \nAbstract: \nViruses are reproductive machineries formed mainly by genetic material (RNA or DNA) and proteins. In general\, these proteins interact with specific proteins of the host forming vast networks of virus-host protein-protein interactions (PPI). Although a virus may infect mainly an organ or system of the host\, the damages can propagate beyond it\, transforming the affection into a multiorganic/multifunctional one. This is the case of SARS-CoV-2\, which makes COVID-19 a multiorganic disease affecting a dozen of organs/systems in humans. Here\, I develop the hypothesis based on facts that this propagation of extrapulmonary damages takes place via the PPI network of virus-host interactions. It considers that some viral proteins interact with specific human proteins highly expressed in the lungs. Then\, these perturbed human proteins navigate outside the lungs via an exosome-mediated transport network\, which allows the inter-organ cross-talk. Due to the fact that these “perturbated” proteins interact with their partners in other organs they are capable to transmit such perturbations beyond the lungs. Therefore\, there is a network of perturbators from the lungs interacting with a network of vulnerable proteins in other organs\, which trigger a range of damages in them. We identify here the perturbators and vulnerable proteins in COVID-19\, identifying 13 organs/systems that may be affected by the infection of SARS-CoV-2 and explain some of the extrapulmonary damages observed in clinics. We propose a series of drugs that can be repurposed to treat combinations of these damages in COVID-19 patients. Finally\, at a lower size-scale we zoom on these SARS-CoV-2 proteins to investigate their topological structure\, which form other networks of amino-acids interacting noncovalently among them. Using these techniques\, we are able to identify weak pints in such proteins that can be used as pharmacological targets. \nestrada_bifitalks2021 \n16 APRIL 12:30\nONLINE: WEBINAR ZOOM\nLink: https://us02web.zoom.us/j/84993664074
URL:https://bifi.es/schedule/bifi-talk-dr-ernesto-estrada/
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