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X-WR-CALDESC:Events for BIFI -  - Institute for Biocomputation and Physics of Complex Systems
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DTSTART;TZID=Europe/Madrid:20240508T123000
DTEND;TZID=Europe/Madrid:20240508T143000
DTSTAMP:20260422T010601
CREATED:20240430T082513Z
LAST-MODIFIED:20240516T083246Z
UID:8090-1715171400-1715178600@bifi.es
SUMMARY:BIFI TALK: Narimantas Cenas\, Vilnius University of Lituania
DESCRIPTION:BIFI TALK: Narimantas Cenas\, Vilnius University of Lituania \nTitle: Single- and two-electron reduction of nitroaromatic compounds by\nflavoenzymes: mechanisms and implications for cytotoxicity \nWednesday\, 8th May 2024\, 12:30 h\nEdificio I+D (Conference room)
URL:https://bifi.es/schedule/bifi-talk-narimantas-cenas-vilnius-university-of-lituania/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Events
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240514T100000
DTEND;TZID=Europe/Madrid:20240514T130000
DTSTAMP:20260422T010601
CREATED:20240430T083311Z
LAST-MODIFIED:20240516T084426Z
UID:8094-1715680800-1715691600@bifi.es
SUMMARY:Webinar Digital Genres and Open Science
DESCRIPTION:M José Luzón and Carmen Pérez-Llantada (Digital Science Lab \nComputing and Data ScienceBIFI) cordially invite you to participate in the webinar “Digital Genres and Open Science”\, which will take place on Tuesday\, 14 May 2024\, from 10:00 to 13:00 (Madrid time). \nThe webinar will consist of three sessions dedicated to the presentation of our findings on digital genres for the promotion and dissemination of science. This presentation will be followed by a multidisciplinary round table (in Spanish): Oportunidades y retos de la comunicación digital) on the opportunities and challenges of open science. \nA member of BIFI (Olga Abián) and members of Fundación Ibercivis (Francisco Sanz and Daniel Lisbona) are some of the invited speakers in this round table! See the programme on our website (https://genci.unizar.es/dissemination-event/) \nThe webinar is aimed at linguists with an interest in digital genres and researchers who wish to disseminate their research on the web. To attend\, please complete the registration form here: https://docs.google.com/forms/d/e/1FAIpQLSelvvz006mRNM9F5HRVrnL2heR9vfRsu00M8Bk70qJV4L1ZLg/viewform
URL:https://bifi.es/schedule/webinar-digital-genres-and-open-science/
LOCATION:Online
CATEGORIES:Events
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DTSTART;TZID=Europe/Madrid:20240524T130000
DTEND;TZID=Europe/Madrid:20240524T150000
DTSTAMP:20260422T010601
CREATED:20240516T084936Z
LAST-MODIFIED:20240516T085043Z
UID:8098-1716555600-1716562800@bifi.es
SUMMARY:BIFI TALK: Athi N Naganathan\, Indian Institute of Technology Madras (IITM)\, Chennai\, India
DESCRIPTION:BIFI TALK: Athi N Naganathan\, Indian Institute of Technology Madras (IITM)\, Chennai\, India \nTitle:  Conformational Tuning as a Mechanism to Determine Specificity and\nPromiscuity \nAbstract: \nParalogous proteins confer enhanced fitness to organisms via complex sequence-conformation codes that shape functional divergence\, specialization\, or promiscuity. Here\, we resolve the underlying mechanism of promiscuous binding versus partial sub-functionalization by studying paralogous Acyl-CoA Binding Proteins (ACBPs) from Plasmodium falciparum. Combining experiments and simulations on two of the paralogs\, A16 and A749\, we show that minor sequence differences shape nearly every conformational feature. A749 displays a heterogeneous native ensemble\, weaker thermodynamic coupling\, enhanced fluctuations\, and a larger binding-pocket volume\, compared to A16. Tryptophan probes signal a graded reduction in the sampling of substates in the holo form\, hinting at conformational-selection-like mechanism of binding. They exhibit a spectrum of binding affinities to acyl-CoAs with A749\, the\nmore promiscuous and hence the likely ancestor\, binding 1000-fold stronger to Lauroyl-CoA. We thus demonstrate how minor differences in long-range coupling and dynamics contribute to the evolution of contrasting functional repertoires in paralogs. \n  \nFRIDAY\, 24th May 2024\, 13:00 h\nEdificio I+D (Aula room)
URL:https://bifi.es/schedule/bifi-talk-athi-n-naganathan-indian-institute-of-technology-madras-iitm-chennai-india/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Events
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