BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//BIFI -  - Institute for Biocomputation and Physics of Complex Systems - ECPv6.15.11//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:BIFI -  - Institute for Biocomputation and Physics of Complex Systems
X-ORIGINAL-URL:https://bifi.es/es/
X-WR-CALDESC:Eventos para BIFI -  - Institute for Biocomputation and Physics of Complex Systems
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231124T120000
DTEND;TZID=Europe/Madrid:20231124T140000
DTSTAMP:20260424T210907
CREATED:20230912T074821Z
LAST-MODIFIED:20231114T093831Z
UID:7411-1700827200-1700834400@bifi.es
SUMMARY:BIFI TALK: Cristina Mayor Ruiz. IRB Barcelona (Barcelona\, Spain)
DESCRIPTION:BIFI TALK: CRISTINA MAYOR RUIZ \nTitle: Targeted protein degradation: Chasing molecular glues and coping with resistance to degraders \n  \nAbstract: \nTargeted protein degradation is a pharmacological strategy based on drugs (degraders) that destroy proteins by hijacking the intracellular proteolysis machinery. This strategy has garnered significant attention in the last year owing to its potential to modulate the abundance of proteins that are difficult to target with conventional inhibitors. Degraders can be multivalent (PROTACs) or monovalent (molecular glue degraders) depending on the number of chemical warheads. Molecular glue degraders offer a promising strategy for targeting disease-relevant proteins that were previously considered «undruggable». Mechanistically\, they orchestrate direct protein-protein interactions between a target protein and an E3 ubiquitin ligase.  As a result\, the target protein gets ubiquitinated and then degraded by the proteasome. Despite their great therapeutic potential\, the discovery of molecular glue degraders has been largely serendipitous. I will discuss our efforts to facilitate the rational development of molecular glues. \nIn addition\, many genetic determinants governing degrader efficiency have been mapped in recent years\, bringing important lessons about resistance mechanisms. Our recent chemoproteomics journey aimed at identifying strategies to overcome broad resistance to degraders will be presented. \n  \nFRIDAY\, 24th November 2023\, 12:00 h\nEdificio I+D (Conference room) \n  \n 
URL:https://bifi.es/es/schedule/bifi-talk-cristina-mayor-ruiz/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Eventos
END:VEVENT
END:VCALENDAR