BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//BIFI -  - Institute for Biocomputation and Physics of Complex Systems - ECPv6.15.11//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://bifi.es/es/
X-WR-CALDESC:Eventos para BIFI -  - Institute for Biocomputation and Physics of Complex Systems
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20180325T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20181028T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T130000
DTEND;TZID=Europe/Madrid:20191004T140000
DTSTAMP:20260426T074030
CREATED:20190310T193037Z
LAST-MODIFIED:20190917T070914Z
UID:5159-1570194000-1570197600@bifi.es
SUMMARY:BIFI TALK - Javier García-Nafría
DESCRIPTION:Título: Cryo-electron microscopy: moving beyond X-ray crystallography for membrane receptors and drug discovery\n \nPonente: Javier García-Nafría (LMB/MRC\, Cambridge\, UK-University of Zaragoza) \nDía y hora:  4 de octubre a las 13:00 h \nLugar: SALA DE CONFERENCIAS\, EDIFICIO I+D+i\, CAMPUS RIO EBRO \nResumen: \nCryo-electron microscopy (cryo-EM) has undergone major advances during the last years\, with special impact in structural biology of membrane proteins. I will review the advances in cryo-EM technology that made the ¨resolution revolution¨ possible\, and then show its application to understand G-protein coupled receptors (GPCRs). GPCRs are the largest family of membrane proteins in the human body and are a target for ~35% of the currently approved FDA drugs. GPCRs sense a variety of molecules and transduce the signal to the intracellular milieu by coupling to heterotrimeric G-proteins. We used cryo-EM to obtain high-resolution structural information on GPCR-G protein complexes\, starting to tackle one of the major questions in the field – the GPCR-G protein selectivity code. I will then analyse the state-of-the-art in using cryo-EM for structure-based drug discovery of membrane proteins. \nReferences: \n\nCryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein. García-Nafría J.*\, Lee Y.*\, Bai X.\, Carpenter B. & Tate CG. 2018. Elife. May 4;7. pii: e35946.\n\n\nCryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go. García-Nafría J.\, Nehme R.\, Edwards P.\, Tate CG. 2018. Nature 558 (7711). 620-62\n\n\nCryo-EM structures of GPCRs coupled to Gs\, Gi and Go.  García-Nafría J. and Tate CG. Molecular and Cellular Endocrinology. 2019\, In press.\n\n\nCryo-Electron Microscopy: Moving Beyond X-ray Crystal Structures for Drug receptors and Drug development. García-Nafría J. and Tate CG. 2019. Annual Reviews in Pharmacology and Toxicology. 2020. In press (2019 Jul 26. doi: 10.1146.)\n\n\n 
URL:https://bifi.es/es/schedule/bifi-talk-javier-garcia-nafria/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Eventos
END:VEVENT
END:VCALENDAR