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X-WR-CALDESC:Eventos para BIFI -  - Institute for Biocomputation and Physics of Complex Systems
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DTSTART;TZID=Europe/Madrid:20231004T100000
DTEND;TZID=Europe/Madrid:20231004T120000
DTSTAMP:20260424T205100
CREATED:20230912T074343Z
LAST-MODIFIED:20231003T090534Z
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SUMMARY:II Ciclo de seminarios de jóvenes investigadores: Patricia Bruñen
DESCRIPTION:Diseño y síntesis de derivados del FMN para su unión covalente con la apoflavodoxina de Anabaena. PATRICIA BRUÑEN \n  \nMiércoles\, 4 de octubre\, 2023 \n10:00-12:00 h \nEdificio I+D
URL:https://bifi.es/es/schedule/ii-cycle-of-young-researcher-seminars-patricia-brunen/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Eventos
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DTSTART;TZID=Europe/Madrid:20231009T120000
DTEND;TZID=Europe/Madrid:20231009T143000
DTSTAMP:20260424T205100
CREATED:20230926T074307Z
LAST-MODIFIED:20230926T074307Z
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SUMMARY:TALK: Prof.Derek Bowie. McGill University\, Montreal\, Canada
DESCRIPTION:Re-imagining the glutamatergic synapse: From structure-function to neurological disease\nProfessor Derek Bowie. Department of Pharmacology & Therapeutics\, McGill University\, Montreal\, Canada \nAbstract:\nThe Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs)\, GABA-A receptors and more recently\, sodium and potassium channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. autism\, schizophrenia)\, cerebral insult (e.g. stroke\, epilepsy) and aging disorders (e.g. Alzheimer’s disease\, Parkinsonism). We are looking at iGluRs\, GABA-A receptors\, Na+ and K+ channels at two inter-related levels. In molecular terms\, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level\, we are studying the role they fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states. The talk will focus on recent work from the lab on a subclass of iGluRs\, called AMPA receptors. \nBiosketch:\nDr. Derek Bowie is a Professor of Pharmacology & Therapeutics at McGill University and co-Director of the Cell Information Systems. The Bowie lab focuses on several major ion-channel families with a special emphasis on their role in neurodevelopmental disorders. Dr. Bowie earned his Ph.D. at the University of London after completing his undergraduate degree at Strathclyde University in Scotland. He then carried out postdoctoral training in France (Université Louis Pasteur)\, Switzerland (Universität Zürich) and the US (National Institutes of Health) before taking a faculty position at Emory University (Atlanta\, GA\, USA). He started his research program at McGill in 2002 and is currently a Full Professor. He was recently a Visiting Professor in Japan (Natl. Institutes for Physiological Sciences). He is the recipient of the Canada Research Chair award in Receptor Pharmacology and has served on numerous national and international advisory panels including IBRO. He also serves/has served on several editorial boards including the Journal of Physiology\, Current Neuropharmacology\, Channels\, Current Opinion in Physiology and Frontiers in Neural Circuits. In 2022\, he co-founded the McGill spin-off company\, Nospharma\, to develop and bring to market therapeutics for the treatment of rare neurological disorders. \n  \n9th October\, 2023 \nSalón de Actos\, Edificio I+D \n12 h
URL:https://bifi.es/es/schedule/talk-prof-derek-bowie-mcgill-university-montreal-canada/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Eventos
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DTSTART;TZID=Europe/Madrid:20231020T120000
DTEND;TZID=Europe/Madrid:20231020T140000
DTSTAMP:20260424T205100
CREATED:20230912T073949Z
LAST-MODIFIED:20231016T093353Z
UID:7398-1697803200-1697810400@bifi.es
SUMMARY:BIFI TALK: Salvatore Adinolfi. Department of Drug Science and Technology\, University of Turin\, Italy
DESCRIPTION:BIFI TALK: SALVATORE ADINOLFI. Department of Drug Science and Technology\, University of Turin\, Italy \nTítulo: The contradictory role of frataxin in Fe-S cluster biogenesis \nAbstract: \nFrataxin is a small mitochondrial protein whose limited expression impairs Fe-S cluster biogenesis and promotes iron accumulation\, leading to the neurodegenerative Friedreich’s ataxia. Although frataxin role is yet to be completely unraveled\, its involvement as a regulator of the desulfurase activity in the Fe-S cluster biogenesis machinery has been demonstrated for both human frataxin and its bacterial ortholog CyaY. In this frame\, although the human and the bacterial proteins share high homology in their aminoacidic sequence and tridimensional structure\, a dramatic discrepancy has been highlighted by in vitro studies addressing their effect on the Fe-S cluster formation machinery. In particular\, while CyaY slows down the kinetics of Fe-S cluster formation on IscU\, human frataxin has emerged as an activator of Fe-S cluster biogenesis. In this review it will be described all the information to better understand the evolutionary divergence of the frataxin genes. \nIt is difficult to clarify this apparent paradox by studying the process in vitro where the isolated proteins are in an artificial environment or in vivo under non-controlled conditions. To clarify the issue\, we have used a new approach based on metabolomics to study the enzymatic reaction. We followed the enzymatic kinetics ex vivo using bacterial to investigate enzymatic kinetics of IscS and the role that frataxin plays in it. We prove that IscS is inhibited by bacterial frataxin even in this ex vivo condition. We also prove conclusively that iron acts as the effector of the reaction in prokaryotes. This study provides a new powerful tool for the study of iron sulfur cluster biogenesis. \n  \nFRIDAY\, 20 de octubre de 2023\, 12:00 h\nEdificio I+D (Sala de Conferencias
URL:https://bifi.es/es/schedule/bifi-talk-salvatore-adinolfi/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Eventos
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