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DTSTART;TZID=Europe/Madrid:20231109T100000
DTEND;TZID=Europe/Madrid:20231109T120000
DTSTAMP:20260424T193641
CREATED:20230912T075339Z
LAST-MODIFIED:20231103T075225Z
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SUMMARY:II Ciclo de seminarios de jóvenes investigadores: Pablo Valgañón
DESCRIPTION:«Procesos de reacción-difusión y estrategias de control epidémico». PABLO VALGAÑÓN \n  \nWednesday\, 8th November\, 2023\n10:00-12:00 h\nSalón de actos.Edificio I+D
URL:https://bifi.es/es/schedule/ii-cycle-of-young-researcher-seminars-pablo-valganon/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Eventos
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231117T113000
DTEND;TZID=Europe/Madrid:20231117T140000
DTSTAMP:20260424T193641
CREATED:20231114T122305Z
LAST-MODIFIED:20231114T130050Z
UID:7724-1700220600-1700229600@bifi.es
SUMMARY:Seminario web Digital Language and Communication Training for EU Scientists
DESCRIPTION:Seminario web Digital Language and Communication Training for EU Scientists\, proyecto Erasmus + financiado por la Comisión Europea (Proyecto nº 2022-1-ES01-KA220-HED-000086749)\, que tendrá lugar este próximo viernes día 17 de noviembre a las 12.30h. \nEn este seminario se harán breves presentaciones del consorcio\, sus objetivos y sus actividades previstas\, relacionadas con los siguientes temas: \n– Etnografías de prácticas de comunicación digital de la ciencia\n– Desarrollo de recursos digitales para la formación de investigador@s en comunicación profesional y pública de la ciencia\n– Pilotaje\, validación e implementación de formación online\n– Desarrollo de la infraestructura tecnológica del proyecto y de sus recursos de formación \nSe adjunta el programa y unas infografias sobre DILAN. \nLa inscripción es gratuita y se puede realizar en el siguiente enlace. Se certificará la asistencia: \nhttps://forms.gle/fPMjUQQWVDq4sGJU7 \n  \n 
URL:https://bifi.es/es/schedule/seminario-web-digital-language-and-communication-training-for-eu-scientists-2/
LOCATION:Online
CATEGORIES:Eventos
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231124T120000
DTEND;TZID=Europe/Madrid:20231124T140000
DTSTAMP:20260424T193641
CREATED:20230912T074821Z
LAST-MODIFIED:20231114T093831Z
UID:7411-1700827200-1700834400@bifi.es
SUMMARY:BIFI TALK: Cristina Mayor Ruiz. IRB Barcelona (Barcelona\, Spain)
DESCRIPTION:BIFI TALK: CRISTINA MAYOR RUIZ \nTitle: Targeted protein degradation: Chasing molecular glues and coping with resistance to degraders \n  \nAbstract: \nTargeted protein degradation is a pharmacological strategy based on drugs (degraders) that destroy proteins by hijacking the intracellular proteolysis machinery. This strategy has garnered significant attention in the last year owing to its potential to modulate the abundance of proteins that are difficult to target with conventional inhibitors. Degraders can be multivalent (PROTACs) or monovalent (molecular glue degraders) depending on the number of chemical warheads. Molecular glue degraders offer a promising strategy for targeting disease-relevant proteins that were previously considered «undruggable». Mechanistically\, they orchestrate direct protein-protein interactions between a target protein and an E3 ubiquitin ligase.  As a result\, the target protein gets ubiquitinated and then degraded by the proteasome. Despite their great therapeutic potential\, the discovery of molecular glue degraders has been largely serendipitous. I will discuss our efforts to facilitate the rational development of molecular glues. \nIn addition\, many genetic determinants governing degrader efficiency have been mapped in recent years\, bringing important lessons about resistance mechanisms. Our recent chemoproteomics journey aimed at identifying strategies to overcome broad resistance to degraders will be presented. \n  \nFRIDAY\, 24th November 2023\, 12:00 h\nEdificio I+D (Conference room) \n  \n 
URL:https://bifi.es/es/schedule/bifi-talk-cristina-mayor-ruiz/
LOCATION:Edificio Institutos I+D\, Mariano Esquillor\, 50018 Zaragoza\, Zaragoza\, Zaragoza\, 50018\, España
CATEGORIES:Eventos
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