{"id":6386,"date":"2021-04-09T13:35:23","date_gmt":"2021-04-09T11:35:23","guid":{"rendered":"http:\/\/bifi.es\/schedule\/bifi-talk-dr-ernesto-estrada\/"},"modified":"2021-04-09T14:07:47","modified_gmt":"2021-04-09T12:07:47","slug":"bifi-talk-dr-ernesto-estrada","status":"publish","type":"tribe_events","link":"https:\/\/bifi.es\/es\/schedule\/bifi-talk-dr-ernesto-estrada\/","title":{"rendered":"BIFI TALK Dr. Ernesto Estrada (ARAID-IUMA-Universidad de Zaragoza)"},"content":{"rendered":"<p><strong>Tittle<\/strong>: Networks Virology. Learning from SARS-CoV-2<\/p>\n<p><strong>Abstract<\/strong>:<\/p>\n<p>Viruses are reproductive machineries formed mainly by genetic material (RNA or DNA) and proteins. In general, these proteins interact with specific proteins of the host forming vast networks of virus-host protein-protein interactions (PPI). Although a virus may infect mainly an organ or system of the host, the damages can propagate beyond it, transforming the affection into a multiorganic\/multifunctional one. This is the case of SARS-CoV-2, which makes COVID-19 a multiorganic disease affecting a dozen of organs\/systems in humans. Here, I develop the hypothesis based on facts that this propagation of extrapulmonary damages takes place via the PPI network of virus-host interactions. It considers that some viral proteins interact with specific human proteins highly expressed in the lungs. Then, these perturbed human proteins navigate outside the lungs via an exosome-mediated transport network, which allows the inter-organ cross-talk. Due to the fact that these \u00abperturbated\u00bb proteins interact with their partners in other organs they are capable to transmit such perturbations beyond the lungs. Therefore, there is a network of perturbators from the lungs interacting with a network of vulnerable proteins in other organs, which trigger a range of damages in them. We identify here the perturbators and vulnerable proteins in COVID-19, identifying 13 organs\/systems that may be affected by the infection of SARS-CoV-2 and explain some of the extrapulmonary damages observed in clinics. We propose a series of drugs that can be repurposed to treat combinations of these damages in COVID-19 patients. Finally, at a lower size-scale we zoom on these SARS-CoV-2 proteins to investigate their topological structure, which form other networks of amino-acids interacting noncovalently among them. Using these techniques, we are able to identify weak pints in such proteins that can be used as pharmacological targets.<\/p>\n<p><a href=\"https:\/\/bifi.es\/wp-content\/uploads\/2021\/04\/estrada_bifitalks2021.pdf\">estrada_bifitalks2021<\/a><\/p>\n<p>16 APRIL 12:30<br \/>\nONLINE: WEBINAR ZOOM<br \/>\nLink:\u00a0<a href=\"https:\/\/us02web.zoom.us\/j\/84993664074\">https:\/\/us02web.zoom.us\/j\/84993664074<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tittle: Networks Virology. Learning from SARS-CoV-2 Abstract: Viruses are reproductive machineries formed mainly by genetic material (RNA or DNA) and proteins. In general, these proteins interact with specific proteins of [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[33],"class_list":["post-6386","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-eventos","cat_eventos"],"_links":{"self":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events\/6386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/users\/8"}],"version-history":[{"count":4,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events\/6386\/revisions"}],"predecessor-version":[{"id":6396,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events\/6386\/revisions\/6396"}],"wp:attachment":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/media?parent=6386"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tags?post=6386"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events_cat?post=6386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}