BIFI-TALK: James Krieger. CNB-CSIC, Madrid<\/p>\n
Title:\u00a0<\/strong>A Perspective on CryoEM, Heterogeneity and Dynamics<\/p>\n Abstract<\/strong><\/p>\n Proteins are dynamic objects that change their shape (conformation) and move around and interact with other molecules (composition) to carry out functions. Cryogenic electron microscopy (CryoEM) is a valuable technique for capturing the resulting heterogeneity, thanks to many developments in hardware and software.<\/p>\n Nevertheless, understanding dynamics and function from CryoEM is still a challenge. The last few years has seen a second revolution in image processing to handle heterogeneity in new ways, driven by developments in machine learning.Many new approaches have been tried, giving the field much to think about.<\/p>\n I will reflect on the challenges of analysing CryoEM images and the successes and limitations achieved with new heterogeneity methods, focusing on two methods developed in our lab: Zernike3D and HetSIREN.<\/p>\n I will give examples based on synthetic data, widely used public data sets and specific systems that we have studied, particularly the coronavirus Spike protein.<\/p>\n Thursday, 11 February 2025, 12:30 h <\/p>\n","protected":false},"excerpt":{"rendered":" BIFI-TALK: James Krieger. CNB-CSIC, Madrid Title:\u00a0A Perspective on CryoEM, Heterogeneity and Dynamics Abstract Proteins are dynamic objects that change their shape (conformation) and move around and interact with other molecules […]<\/p>\n","protected":false},"author":8,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[33],"class_list":["post-8498","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-eventos","cat_eventos"],"_links":{"self":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events\/8498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/users\/8"}],"version-history":[{"count":1,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events\/8498\/revisions"}],"predecessor-version":[{"id":8499,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events\/8498\/revisions\/8499"}],"wp:attachment":[{"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/media?parent=8498"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tags?post=8498"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/bifi.es\/es\/wp-json\/wp\/v2\/tribe_events_cat?post=8498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nConference Room. Edificio I+D<\/p>\n