Eventos

Title:Challenges and advances in the training of Energy-Based Models: theoretical insights on non-equilibrium sampling and overfitting Abstract In the context of unsupervised learning and generative models in artificial intelligence, energy-based models (EBMs) provide a simple way to describe arbitrary complex datasets, by encoding their empirical distribution into a Boltzmann probability law with a given energy […]

BIFI-TALK: James Krieger. CNB-CSIC, Madrid Title: A Perspective on CryoEM, Heterogeneity and Dynamics Abstract Proteins are dynamic objects that change their shape (conformation) and move around and interact with other molecules (composition) to carry out functions. Cryogenic electron microscopy (CryoEM) is a valuable technique for capturing the resulting heterogeneity, thanks to many developments in hardware and […]

BIFI TALK: Ángel Pérez Lara, Universidad de Granada Title: Molecular mechanism of neurotransmitter release machinery Abstract Transmission of information between neurons relies on the neurotransmitter release from synaptic vesicles into the synaptic cleft upon the influx of Ca2+, a process known as synaptic exocytosis. Synaptic exocytosis is mediated by the SNARE proteins syntaxin 1 (syx-1A), […]