Ignacio Marchante Hueso

Centre: Dpt. Física Teórica/IUI BIFI
Institution: University of Zaragoza, Zaragoza (Spain)
Position: PhD Student
E-mail: ignacio.marchante@bifi.es
Phone: 976762989
Profile:  Ver

Personal statement
After completing my undergraduate studies in Physics in 2020, I completed a Master’s degree in Quantitative Biotechnology at the University of Zaragoza in 2021. Afterwards, I started my PhD studies, which are developed within an interdisciplinary co-supervision program funded by the UNITA consortium, between the PhD programs in Physics (Unizar), and Complex Systems Biology (University of Turin). During my thesis, I have been involved in multiple international collaborations with different universities such as Chicago, Turin, and Naples, where I was a visiting researcher in 2022. My research career has allowed me to collaborate with a rich network of collaborators that include experts in Complex Systems Physics, experimental and computational genomics, as well as medicine, microbiology and immunology, awakening my passion for multidisciplinary research.

Researcher profile identity
Currently, I am a predoctoral researcher (R1 level), and my work focuses on analyzing how heterogeneity between individuals affects immune function, and consequently, the susceptibility and presentation of various diseases with a significant component of immune dysregulation. My research focuses on studying factors such as genetics, age and sex, and their influence on the regulation of key genes and proteins. To this end, I develop new computational methods that allow for robust statistical analysis of genomic and proteomic data from large cohorts of patients. These tools are applied in interdisciplinary studies, collaborating with teams from different areas to better understand individual variability and its impact on complex diseases, such as infectious and autoimmune diseases. The ultimate goal of my work is to identify patterns that can be used to develop more personalized approaches in medicine, improving risk prediction and therapeutic strategies.

Why my research is important
The relevance of my work is twofold. On the one hand, from a methodological perspective, the development of new computational tools for the analysis and integration of omics data of different nature and scale is very useful for exploring new hypotheses in the field. In itself, constitutes an important focus of activity in computational biology, within which part of my activity is framed. On the other hand, from an applied and translational perspective, the multidisciplinary research in which I am involved helps to understand in great detail the cellular mechanisms involved in different diseases and how these vary between different people. This is important in order to develop more personalised strategies in medicine that optimise the benefits of drugs in society, in different pathologies such as celiac disease or chronic stress, among others.

Know more about me and my research
– https://sanzlab.wordpress.com/