Events

BIFI TALK: Athi N Naganathan, Indian Institute of Technology Madras (IITM), Chennai, India Title:  Conformational Tuning as a Mechanism to Determine Specificity and Promiscuity Abstract: Paralogous proteins confer enhanced fitness to organisms via complex sequence-conformation codes that shape functional divergence, specialization, or promiscuity. Here, we resolve the underlying mechanism of promiscuous binding versus partial sub-functionalization […]

BIFI-Talk: Sara García Linares. Universidad Complutense de Madrid. Title: Design of nanoreactors for plastic depolymerization based on pore-forming toxins Abstract Petroleum-based plastics are durable and accumulate in all ecological niches. Approximately 80% of waste objects are made of macroplastics, with most ending up dumped into the oceans. PET (polyethylene terephthalate) is the primary component in […]

BIFI TALKS: Sylvie Callegari, del Eliza Hall Institute of Medical Research, Australia Title: Activating PINK1 to treat Parkinson’s disease Abstract PINK1, a protein linked to Parkinson's disease, is a ubiquitin kinase that accumulates on the outer membrane of damaged mitochondria. Upon accumulation, PINK1 becomes activated and phosphorylates ubiquitin, generating a unique phospho-ubiquitin signal that triggers […]

BIFI TALK: José Manuel Martín García, del Instituto Blas Cabrera, CSIC, Madrid Title: Time-resolved structural studies with serial crystallography: A new frontier in biomedical research. Abstract Structural biology, especially X-ray crystallography, has significantly advanced our understanding of diseases by revealing the 3D structures of proteins. However, traditional X-ray crystallography encounters challenges, such as difficulties in obtaining […]

BIFI TALK: David Fernández-Antorán. Gurdon Institute, Cambrigde and ARAID-IIS Aragón Title: Epithelioids: Long-term and self-maintained primary 3D cultures to study tissue behaviour in vitro Abstract This talk will introduce "Epithelioids," a novel 3D primary epithelial culture system that enables the long-term, self-sustaining growth of tissues derived from both normal and tumour samples. Epithelioids maintain the proliferation, […]

BIFI TALK: Ariadna Pié Porta, Department of Chemical and Biochemical Engineering, Technical University of Denmark Title:Oxidases and their Michaels Constant for Oxygen: Relevance and Measurement Abstract Medicine has benefited from the great features of enzymes for many years. During the past decades, the interest in the application of enzymes as (bio)catalysts to produce a wide […]

BIFI TALK: Francisco Ciruela, Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain. Neuropharmacology and Pain Group, Neuroscience Program, Institut d’Investigació Biomèdica de Bellvitge, IDIBELL, 08907 L’Hospitalet de Llobregat, Spain. Title: Adenosine receptor heteromers: biasing antipsychotics Abstract The striatal dopamine D2 receptor (D2R) […]

Title:Challenges and advances in the training of Energy-Based Models: theoretical insights on non-equilibrium sampling and overfitting Abstract In the context of unsupervised learning and generative models in artificial intelligence, energy-based models (EBMs) provide a simple way to describe arbitrary complex datasets, by encoding their empirical distribution into a Boltzmann probability law with a given energy […]

BIFI-TALK: James Krieger. CNB-CSIC, Madrid Title: A Perspective on CryoEM, Heterogeneity and Dynamics Abstract Proteins are dynamic objects that change their shape (conformation) and move around and interact with other molecules (composition) to carry out functions. Cryogenic electron microscopy (CryoEM) is a valuable technique for capturing the resulting heterogeneity, thanks to many developments in hardware and […]